The process of Sustanon 250 17-alpha alkylation has been shown to be an effective means of stabilizing the drug in vivo, but this also makes the drug extremely toxic to the liver, resulting in side effects such as jaundice, liver cancer and other metabolic disorders that occur when liver cells die. buy sustanon 250 Intrahepatic cholestasis is also rather common. The liver produces a compound called bile, which is stored in the gallbladder and enters the stomach through the bile duct. Bile, when combined with lipase, aid in the digestion of fats in the stomach and small intestine. Intrahepatic cholestasis is a condition that causes the bile to clog the main bile pathway out of the liver to the gallbladder - a very serious condition that can not only damage the liver, but the gastrointestinal tract as well. The reason 17-alpha alkylated oral steroids are still used is because athletes still would rather take the risk in an effort to see gains in muscle strength and size.
Other oral steroids have been combined with lipophilic side chains in effort to increase the stability and activation of the steroid once it has been ingested into the body. After initial ingestion, the steroid tablet or pill will flow through the stomach, where it is bombarded with chyme, lipase, hydrochloric acid and bile before making its way past the duodenum and into the small intestine for absorption. Once in the small intestine, the steroid will be absorbed into portal circulation and shuttled directly to the liver for processing. As discussed above, if the steroid is 17 alpha alkylated, it will survive this first pass, but not without damaging the liver itself. However, in addition to the portal circulation, there is another pathway that nutrients can take in the small intestine. If a substance is fatty in nature (lipophilic), it will be absorbed as dietary fat, which is incorporated into chylomicra (small fat globules comprised of fat and protein). Rather than being absorbed into portal circulation and shuttled to the liver, the nutrients are absorbed directly into lymphatic circulation, which bypasses the liver entirely. Therefore, researchers have added a lipophilic component to the steroid backbone in an effort to maximize absorption and bypass the first pass through the liver Even with these modifications, lipophilically modified steroids are still not absorbed, nor are they activated, as readily as 17-alpha alkylated steroids. Therefore, Sustanon 250 steroids that are considered lipophilic, such as Testosterone undecanoate, are not very powerful and will not be an effective drug to use to increase strength and muscle mass. The reason lipophilic steroids are not effective is that there is high variability in the amount of absorption not only between individuals, but between doses with the same individual. When an athlete takes the drug can affect how much of it will be absorbed. Diet also plays a role in this. In diets that are high in fat intake (such as when a bodybuilder is on a bulk cycle), the natural fatty acid intake will limit the amount of steroids that can be taken up as chylomicra in the small intestine. This will further limit the bioavailability of the steroid. The same is true with steroids comprised of an enyl ether.